[Resources-online talks] Cryo-EM Validation in the Age of SARS-CoV-2: Methods, Tools and Applications

CCP-EM will hold a 3-day online seminar (conference?) for the SARS-CoV-2 related projects. For details and registration link, click here.

The speakers and schedule are:

Wednesday 18th November – Analysis and validation of SARS-CoV-2 EM structures

  • 14:00 – 17:15 Main session
  • Peter Rosenthal (Crick)
  • Ardan Patwardhan (EMBL-EBI) “SARS-CoV-2 structures in EMDB and EMPIAR”
  • Patrick Cramer (MPI Göttingen) “Structural studies of SARS-CoV-2 polymerase and mechanism of remdesivir inhibition”
  • Christiane Schaffitzel (Bristol) “A free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein”
  • Beata Turoňová (EMBL) “In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges”
  • Donald Benton (Crick) “Structural basis of SARS-CoV-2 Receptor Binding”
  • Andrea Thorn (Hamburg) “Findings from the Coronavirus Structural Task Force”
  • Tristan Croll (Cambridge) “Rebuilding SARS-CoV-2 Cryo-EM structures with ISOLDE”
  • Agnel Joseph (STFC) “Reprocessing and validation of structures from SARS-CoV-2 and a web service for mapping genome mutations”
  • 17:30 – 18:00 Panel discussion

Thursday 19th November – Single particle map and tomogram validation

  • 14:00 – 17:15 Main session
  • Dmitry Lyumkis (Salk)
  • Tim Grant (UW-Madison)
  • Carsten Sachse (Jülich)“Significance and confidence of cryo-maps and resolution values”
  • Sjors Scheres (MRC-LMB Cambridge) “Single-particle cryo-EM to atomic resolution”
  • Daven Vasishtan (Oxford)
  • Niko Grigorieff (Brandeis) “Locating molecular assemblies by template matching in 2D and 3D: a comparison”
  • Giulia Zanetti (Birkbeck) “Common issues in subtomogram averaging: my perspective on current needs and validation”
  • Mauro Maiorca (Birkbeck)
  • 17:30 – 18:00 Panel discussion

Friday 20th November – Map-model validation

  • 14:00 – 17:15 Main session
  • Martyn Winn (STFC) “Cryo-EM validation tools in CCP-EM”
  • Keitaro Yamashita (MRC-LMB Cambridge) “Refinement of high resolution cryo-EM SPA structures with symmetry”
  • Rangana Warshamanage (MRC-LMB Cambridge) “EMDA validation tools as applied to recent SARS-CoV-2 Structures”
  • Andrei Istrate (EMBL-EBI) “Strudel – model-dependent map-feature validation and application to EM SARS-CoV-2 structures”
  • Paul Adams (LBL) “Cryo-EM tools in Phenix for validation and beyond”
  • Gerard Kleywegt (EMBL-EBI) “Validation at EMDB and wwPDB”
  • Cathy Lawson (Rutgers) “EMDataResource Validation Challenges: Overview and Outcomes”
  • Zhe Wang (EMBL-EBI) “EM Validation analysis from EMDB”
  • Valeriy Titarenko (Manchester) “Global and local model fitting and scoring for cryo-EM maps”
  • Wah Chiu (Stanford) “Quantitative Measure of Resolvability of CryoEM Density”
  • 17:30 – 18:00 Panel discussion