2025 September: We welcome Pei-Wen to our team as a research assistant. She will be working with Sarah and Kevin to explore the functions of ubiquitin enzymes using molecular regulators. Her background in industry, with expertise in antibodies and radioisotope chemicals, will be a strong asset for investigating diverse applications in ubiquitin enzyme regulation.

2025 July 1: We are pleased to welcome Tracy and Zihui from NTU-IBS as they join our lab for their graduate studies. Congratulations to our Principal Investigator, Dr. Wu, on being elected as a council member of the Taiwan Biophysical Society (July 2025 – June 2028). Dr. Wu has also been appointed to serve a five-year term on the Editorial Board Member of the Journal of Biological Chemistry.

2025 January 20: “Congratulations to Lu-Yi and Kevin on receiving the prestigious 3-year NSTC Graduate Research Fellowship (NSTC-GRF) (Chinese: 國科會博士生研究獎學金)! Their PhD journey will begin in February 2025, and this significant financial support from the government is both an honor and a tremendous help. Wishing them all the best on this exciting adventure!”

2025 January 8: KP received the 2025 Academia Sinica Innovative AI Applications in Humanities and Scientific Research (I-AI-A) Project (AI在人文與科學研究的創新應用計畫). The project “Identify Protein-Protein Interactions with Graph Neural Networks to Precise Protein Design” will facilitate protein design using deep learning approaches.

2024 October 9: 今年諾貝爾化學獎的研究是蛋白質結構相關，是我們的專業。KP也參與了台灣科技媒體中心(SMC)邀請的線上記者會，講述這三位學者的研究。各大報記者也把採訪的內容撰寫成新聞發稿，諸如：自由時報、中央社、ETToday、聯合報等。

2024 September 22: Ben Lo won the Outstanding Poster Award in the IBC annual poster competition in the Frontier Bioorganization Forum held in IBC. His poster topic is related to a novel machine learning tool to discover protein-protein interactions. Stay tuned with us, we will soon send our manuscript for peer review.

2024 August: Kevin and Sarah joined us as research assistants this month. They will be working on the a deubiquitinase project regarding function, regulation, and structural mechanism collaborating with IBC colleagues. Welcome to the ubiquitin family.

2024 May: We welcome a new PostDoc researcher Ben Lo join us. He will be focusing on the development of deep learning-based protein analysis. We also congratulate Sin-Rong Lee, a co-advising NTU-IBS student, for winning the Merit Award for poster competition in the 2024 Taiwan Biophysical Society meeting. Sin-Rong also received the outstanding performance award in the annual NTU-IBS progress report in January 2024.

2024 April 8: We are delighted to announce the official promotion of Dr. Kuen-Phon Wu to the position of tenured Associate Research Fellow. As the principal investigator, Dr. Wu will maintain leadership of the laboratory at the Institute of Biological Chemistry, Academia Sinica. His ongoing dedication will drive further discoveries in the realm of protein function, regulation, and design.

2024 April 3: We are safe! We encountered several strong earthquakes occurred in the morning in Eastern Taiwan (Hualien). The earthquakes were 7.2 magnitude near the epicenter for the first hit and 4.0 – 6.0 for the followed quakes. With many serial quakes in the next 10 hours, the lab located in the Institute of Biological Chemistry, Nankang in Taipei is fine. Everything works as normal. The lab members keep good a habit to secure the storage of glassware and electronics.

2023 November: Congratulations to Principle Investigator Dr. Kuen-Phon Wu for receiving the Academia Sinica Grand Challenge Seed Grant for 2 years. The lab will use this grant to develop AI-related approaches to accelerate protein design and discover of potent regulators for Ubiquitin enzymes.

2023 August: Our summer interns, Chih-Ho and Shih-Tin, successfully presented their 2-month projects and were chosen as outstanding posters. Notably, Chih-Ho earned the exceptional performance award following the oral presentation. The lab is thrilled and extends heartfelt congratulations to both Chih-Ho and Shih-Tin for their dedicated efforts this summer.

2023 July: Warm welcome to NTU-IBS master students Lu-Yi, Keng-Fu, and Yu-Shiuan joining us to study the function, mechanism, and structure of ubiquitin enzymes. We are also pleased to have summer interns Chih-Ho and Shih-Tin join us for 2 months.

2023 June: Congratulations to Pei-Cih for her successful defense for the Master’s degree. The committee is delighted with her work and presentation. We are proud of her performance. She has set high research and thesis standards for the lab members. Big congrats!

2023 April: 恭喜Roy與Pei-Cih分別獲得國科會與台大生科院「研究生出國參與國際會議」的補助。他們兩位將前往美國冷泉港實驗室舉辦的泛素會議。

2023 March: We welcome Chi-Yuan and Rachel to join us as research assistants. They will participate in various projects for protein production, protein design, and structural determination.

2023 January: Big congrats on Roy and Pei-Cih on winning the outstanding awards of the annual NTU-IBS progress reports. We are proud of their performances.
非常恭喜Roy與Pei-Cih在台大生化所年度進度報告中獲得碩士班組優等與佳作。全實驗室與有榮焉，他們兩位在一年多中的研究工作有良好的成績，獲得眾多老師的讚賞。

2022 November: 恭喜本實驗室助理Wendy獲得台大化學系等多個研究所正取！也恭喜暑期生Meihan錄取台大生技系碩士班。

2022 September: After the 2022 annual TMRS meeting, KP was elected as the 9th council members of TMRS. The serving period is 2023 Jan to 2024 Dec.
KP在九月台灣磁共振學會會議中，被票選為第九屆學會理事。任期兩年。

2022 July-August: We welcome Johnson and Wei-Lin joining us as well as our summer intern Meihan (NTU Biotech Dept). Johnson will spend a few years in the laboratory for his doctoral degree, focusing on the structural mechanism of ubiquitination in infectious diseases. Wei-Lin joins us as a RA to assist with sample productions and biophysical experiments.

2022 June: Congratulations to Wendy and Jessica’s JACS paper on the hamster prion fibril structure. They worked very hard in picking fibrils one by one and determined the map of a novel structure of amyloid fibril, which is composed of 4 protofilaments. Congrats!

2022 April: Congratulations to Peggy and other lab members for their hard work determining the structure and mechanism of filamentous Ecoli glutamine synthetase. The work is now online and published in Protein Science. Congrats.

2021 November: We are excited that our undergraduate student, Peggy, has received admission to graduate school from NTU (Chemistry, Institute of Biological Sciences) and NTNU (Chemistry). Congratulations!

2021 July-August: We welcome our new blood Pei-Cih and Roy, joining us. They enroll in IBS-NTU (Institute of Biological Sciences, NTU) for a master’s degree. They will spend 2 years understanding key proteins’ mechanism and structure determination in the ISG15-related pathway. Exciting! We also have new RA Wendy join us in August, who will be responsible for ubiquitin-related sample production and biophysics experiments.

2021 June: Peggy has received full financial support from the Taiwan Magnetic Resonance Society for attending the online meeting of the 22nd international society of resonance conference (ISMAR) (and the 9th Asia-Pacific NMR Symposium, APNMR). The meeting will be held virtually in Osaka, Japan.

2020 Dec 4: KP has received the Career Development Award from Academia Sinica. The award will provide research support for the Wu group for 5 years (2021-2025). Come to work with us.

2020 Nov 1: Congrats Meng-Hsuan, on winning the prize of the poster competition at the TSBMB meeting. We are very proud of his work.

2020 Oct 31: Academia Sinica Open House; KP gave a general introduction of SARS-CoV-2, the importance of papain-like protease, main protease in the drug discovery. (10/31為中研院院區開放日，在一系列的科普演講中，KP於生化所的演講題目為: 冠狀病毒蛋白質切脢的重要性與藥物開發)

2020 July/August: We welcome Yoyo and Shao-Kang join us to work on SARS-CoV-2 COVID-19 related projects for their postdoctoral training.

2020 June: Our former summer intern Peggy has received an 8-month MOST College Student Research grant (科技部大專生研究計畫). She will start to execute the project in 2020 summer focusing on NMR-based analysis of enzyme catalysis and metabolomics.

2020 March 17th: We welcome Jess and Mike join us to work on viral protein and poly- ubiquitination.

2019 Sept 1st: Welcome Ray Lin; join us for his postdoc training in cryoEM and structural biology

2019 August 30th: Summer intern Peggy won the outstanding performance of summer intern program.

2019 August 7th: Wei-Hung’s poster won the “popularity poster” (最佳人氣獎) in the 3rd IBC-CUHK join symposium

2019 August 1st: Warm welcome to Jenny as lab research assistant/technician in X-ray crystallography